After my first blog which is about my own understanding of love, the main focus of our future scenario switched to biotechnology especially in bodily enhancement for aesthetic. This is a literature review to explore one of the most popular applications of biology related to platelet in cosmetic surgery from its original potential and outcomes.
Originally platelet is functioning for haemostasis and wound healing. It constantly exists inside our blood vessel and fluid with blood circulation. The process of tissue healing contains complicated events from both intercellular and extra extracellular which is difficult to be comprehended entirely. However, it can be divided into three overlapping phases which are inflammatory, proliferative and remodelling. The inflammatory is triggered by tissue injury which leads platelet to gather and release growth factor to change its form, which can be described as activation (Eppley, Pietrzak & Blanton 2006). Then the blood in wound area becomes platelet-rich to covered the exposed vessel then initiate blood clotting to prevent blood loss. Then the living tissue could work to replace damaged tissue and reshape itself to resemble the original tissue, which is the last two phases during a wound healing. Thus, platelet is not the key in tissue healing but a protection for further process.
Before the introduction of platelet gels the development of artificial tissue sealing has already begun. Fibrin glue is one of the successful tissue sealants. Its original concept is combining fibrinogen and thrombin which effectively fixed skin grafts by Cronkite et al. and Tidrick and Warner. There is a number of sources to obtain fibrinogen from donors but it also carrying the risk of viral transmission. One reported case is a HIV transmission caused by using homologous product (Bhanot & Alex 2002). Platelet gel, which apheresis from platelet-rich plasma, is easier to produce than high concentration fibrinogen and has both the benefits of fibrin glue and the growth factor for wound healing to reduce infection, pain and blood loss. Man et al. who claimed that combining fibrin glue and platelet gels results numeral benefits in cosmetic surgical procedure including ‘the elimination of the need for drains, a reduction in postoperative pain and swelling, and improved wound healing’ during his study of 20 patients (Eppley, Pietrzak & Blanton 2006, p. 155e).
In conclusion the original function of platelets which is the capability to produce large amount in a short time to help injury healing by assembling clot. Such enhancement provides the evidence of the fact that using autologous platelet-rich plasma could accelerate soft- and hard-tissue healing in some particular situations. Yet the information from my research and the public in present still doubt about the risk of platelet gel injection and fibrin glue especially for facial cosmetic surgery since the entire process of wound healing and haemostasis is not be decrypted. However, this literature review has great inspiration on complete our future scenario in 2040.
Reference
- Bhanot, S. & Alex, J.C. 2002, ‘Current Applications of Platelet Gels in Facial Plastic Surgery, Facial Plastic Surgery, vol. 18, no. 1, pp. 27-33.
- Eppley, B.L., Pietrzak, W.S. & Blanton, M. 2002, Platelet-Rich Plasma: A Review of Biology and Applications in Plastic Surgery, Plastic and Reconstrictive Surgery, vol. 118, no. 6, pp. 147e-159e.